RosettaCommons / RosettaCommons/RFdiffusion
Example of Improved Protein Binder Design Using Beta-Pairing Targeted RFdiffusion
Nobody has claimed this yet.
- Dominant language
- Python
- Stars
- 3.1k
- Forks
- 644
- PR merge metrics
- No merged PRs in 30d
Description
Dear authors,
I hope this message finds you well. I recently read your preprint “Improved protein binder design using beta-pairing targeted RFdiffusion” (doi: 10.1101/2024.10.11.617496) and found the work both exciting and inspiring.
I am very interested in exploring and reproducing the beta-pairing targeted binder design approach you developed. Would it be possible for you to share an example dataset or implementation—perhaps via GitHub—that demonstrates the workflow or inputs/outputs described in your study? Such an example would be invaluable for understanding and applying your method correctly.
I truly appreciate your time and consideration, and I greatly admire your contributions to the field of protein design.
Thank you in advance for your help.
Warm regards,
Luke
Contributor guide
No contributing guide indexed for this repository
First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
- Open a pull request that references the issue number.
Research direction
No repository file, test, or entry point is named. Start by reading the linked preprint and comparing its beta-pairing targeted binder design workflow with the repository's documented inputs and outputs. The issue would be done when a concrete example dataset or implementation is defined and shared, but its scope is not specified.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- python
- Domain
- bioinformatics, machine-learning
- Issue type
- Feature
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 20/100