RosettaCommons / RosettaCommons/RFdiffusion
Issue with Cyclic Peptide Generation
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- Dominant language
- Python
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Description
Hello,
I am a student currently studying protein design in South Korea, and I have been looking into the updated RFpeptide binder design functionality—particularly the generation of cyclic peptides.
When I ran the example script examples/design_macrocyclic_binder.sh, the outputs appeared to be linear peptides, not cyclic ones.
I would be grateful if you could advise whether I may be overlooking any required configurations for cyclic peptide design.
Thank you very much for your time and support.
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Research direction
Start with examples/design_macrocyclic_binder.sh and run the documented example to reproduce the reported linear outputs. Trace the configuration used by the RFpeptide binder design functionality and determine whether cyclic generation requires an additional setting; done means the required behavior is identified and cyclic outputs are produced or the limitation is clearly documented.
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Assessment
- Tech stack
- python, shell
- Domain
- machine-learning
- Issue type
- Bug
- Difficulty
- 4/5
- Estimated time
- 3-5 days
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 32/100