RosettaCommons / RosettaCommons/RFdiffusion
curious to know whether only 3-helix binder protein could be design if using scaffold-based binder design.
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- Dominant language
- Python
- Stars
- 3.1k
- Forks
- 644
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Description
Firstly I used de novo binder design --> only 1-helix binder protein will be designed.
Then, I am using scaffold-based binder design by using the given 1000 scaffolds --> only 3-helix binder protein are designed. (inference.num_designs=10000).
Is it normal?
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Research direction
No files, tests, or entry points are named. Start by comparing the de novo and scaffold-based configurations, including the 1,000 scaffolds and inference.num_designs=10000, then inspect the generated binder structures. Done means establishing whether the three-helix-only result is expected or identifying a reproducible problem.
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Assessment
- Tech stack
- python
- Domain
- bioinformatics, machine-learning
- Issue type
- Bug
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 25/100