RosettaCommons / RosettaCommons/RFdiffusion
10A Cbeta distance of the binder
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- Python
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Description
I have a stupid question to ask, about this sentence "In the paper we define a hotspot as a residue on the target protein which is within 10A Cbeta distance of the binder".
I am working on selecting the specific AA position. Then, I find this sentence. If the "10A Cbeta distance of the binder" is the distance between target to binder, I am confused with it. Because we are going to design the binder, which means we don't know where the binder is, so how to calculate the distance between the target and the binder?
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First steps
- Read the whole issue, then the project's contributing guide.
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Research direction
Read the paper and the surrounding RFdiffusion documentation for the definition of a hotspot and the 10A Cβ distance. Clarify whether the distance refers to a designed binder structure or to another reference, and document how a user should select target amino-acid positions; no repository file or test is named.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- python
- Domain
- bioinformatics, machine-learning
- Issue type
- Documentation
- Difficulty
- 4/5
- Estimated time
- 3-5 days
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 20/100