RosettaCommons / RosettaCommons/RFdiffusion
Existence of Multiple Sequence Alignments (MSA) in Training Process of RFdiffusion Model
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Description
I am currently attempting to fine-tune the RFdiffusion model and working on constructing a dataset. However, I noticed that the model does not require Multiple Sequence Alignment (MSA) at inference time. Do I still need to construct MSA during the training process, or should I solely rely on structural information?
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Research direction
The issue names no files, tests, or entry points. Start by tracing the RFdiffusion training and inference paths to determine whether MSA is required during fine-tuning or structural information is sufficient, then document the confirmed dataset requirements and rationale.
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Assessment
- Tech stack
- python
- Domain
- machine-learning
- Issue type
- Documentation
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 20/100