RosettaCommons / RosettaCommons/RFdiffusion
Looking for recommendations regarding protein-protein docking
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- Dominant language
- Python
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- Forks
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Description
Hi!
In your paper and in this repository, you mention using PatchDock for finding hotspot residues. Would you recommend the more recent DiffDock-PP, whose paper reports to out-perform PatchDock and RifDock? It seemingly also comes at a lower computational cost.
Best,
Contributor guide
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First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
- Open a pull request that references the issue number.
Research direction
Review the repository and the cited paper sections describing PatchDock and hotspot-residue identification, then compare those assumptions with the DiffDock-PP claims mentioned in the issue. Done would be a project-specific recommendation about whether DiffDock-PP is appropriate here, including any relevant computational-cost or workflow tradeoffs.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- python
- Domain
- bioinformatics, machine-learning
- Issue type
- Documentation
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 20/100