RosettaCommons / RosettaCommons/RFdiffusion
How to generate many confirmation from a given PDB or sequence?
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Description
Hi Team, thank you for the great work.
How to generate many confirmation from a given PDB or sequence? I hope RFdiffusion can generate a lot of similar structures. I tried
./scripts/run_inference.py inference.input_pdb=cleaned.pdb inference.num_designs=10 inference.output_prefix=rfdiffusion 'contigmap.contigs=[20-20]'
The cleaned.pdb is 20 aa long. But all the generated confirmations are not similar to cleaned.pdb at all.
Could you please tell me what command I should use?
Thank you.
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Research direction
Start with scripts/run_inference.py and the command in the issue, then check how inference.input_pdb, inference.num_designs, inference.output_prefix, and contigmap.contigs are used. Done means documenting the command or settings needed to generate multiple designs similar to the supplied PDB or sequence.
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Assessment
- Tech stack
- python
- Domain
- bioinformatics, machine-learning
- Issue type
- Documentation
- Difficulty
- 4/5
- Estimated time
- 3-5 days
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 25/100