RosettaCommons / RosettaCommons/RFdiffusion
Guide inpainting
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- Dominant language
- Python
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Description
Hello! Awesome code base and docs!
I’m trying to inpaint a small domain into a loop that of a TM protein that faces the cytosol. However, I keep getting helices to the TM portion in many of my designs. Is there anyway to use conditioning or another trick to guide the design of inpainting? Or would it mostly be choosing designs that are appropriate and then running partial diffusion?
Contributor guide
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First steps
- Read the whole issue, then the project's contributing guide.
- Comment on the issue to say you are picking it up — it saves two people doing the same work.
- Fork the repository and make your change on a branch.
- Open a pull request that references the issue number.
Research direction
The issue does not identify any files, tests, or entry points. Start by locating the inpainting conditioning and partial-diffusion entry points, then determine whether guiding designs away from transmembrane helices requires a documented workflow or a new capability; done means a clear, validated way to control or select these designs.
Written by the indexing model from the issue text.
Assessment
- Tech stack
- python
- Domain
- machine-learning
- Issue type
- Feature
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 25/100