PEtab-dev / PEtab-dev/PEtab

Interaction of parameter bounds and parameter priors

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Description

There have been different interpretations of how parameter bounds and parameter priors interact. The current specifications don't address that explicitly.

My interpretation would be that if a prior distribution exceeds the bounds, the bounds truncate the prior and the probability density needs to be re-scaled accordingly.

The alternative would be, that the prior distribution is not affected by the parameter bounds. This seems weird, since if once really believes that those parameter values outside the bounds have a non-zero probability, then the bounds should have been chosen wider in the first place.

I'd be happy to get other's opinions on that matter.

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Research direction

Start by reviewing the current specifications covering parameter bounds and parameter priors; no specific file, test, or entry point is identified in the issue. Compare the truncation and unaffected-prior interpretations, then clarify the specification so the interaction and any required probability-density rescaling are explicitly defined.

Written by the indexing model from the issue text.

Assessment

Domain
documentation
Issue type
Documentation
Difficulty
5/5
Estimated time
Over a week
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
20/100

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