OpenFreeEnergy / OpenFreeEnergy/openfe

Switch hybridtop unit from using an mdtraj to an openmm topology for hybrid system operations

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Dominant language
Python
Stars
332
Forks
56
Avg merge
3d 9h
Merged PRs (30d)
13

Description

Follow up from #1937

If I remember correctly, this might need fixing the OpenMM Topology creation for the hybrid system (it might not be easy to go from openmm to mdtraj).

Contributor guide

Open the contributing guide

First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start by reading the linked context in issue #1937, then trace the hybrid system operations that currently use an mdtraj topology. Identify where OpenMM topology creation is needed and verify the affected hybrid operations after the switch. Done means those operations use an OpenMM topology without relying on the current mdtraj topology path.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
backend
Issue type
Refactor
Difficulty
4/5
Estimated time
3-5 days
Activity status
Quiet
Clarity
Needs clarification
Newbie friendliness
35/100

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