OpenFreeEnergy / OpenFreeEnergy/openfe

[SepTop] Add warning if restraints are zero?

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Dominant language
Python
Stars
331
Forks
56
Avg merge
3d 9h
Merged PRs (30d)
13

Description

If the restraints are zero across all lambdas, should we be warning users like we do for the ABFE Protocol?

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First steps

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  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Locate the SepTop protocol implementation and compare its restraint handling with the existing ABFE Protocol warning. Determine how zero restraints across all lambdas is represented, then define the warning behavior and verify it with the relevant protocol tests, if available. Done means the intended zero-restraint case is clearly detected and users receive an appropriate warning.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
backend
Issue type
Feature
Difficulty
4/5
Estimated time
3-5 days
Activity status
Quiet
Clarity
Needs clarification
Newbie friendliness
35/100

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