OpenFreeEnergy / OpenFreeEnergy/openfe

SepTop: consider moving equilibrations into separate units

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Dominant language
Python
Stars
332
Forks
56
Avg merge
3d 9h
Merged PRs (30d)
13

Description

Need to review how feasible this is when dealing with badly generated orientational restraints.

Contributor guide

Open the contributing guide

First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start by locating the SepTop implementation and its equilibration handling. Review how badly generated orientational restraints are processed, then document whether moving equilibrations into separate units is feasible and what scope that would require.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
backend
Issue type
Refactor
Difficulty
5/5
Estimated time
Over a week
Activity status
Quiet
Clarity
Needs clarification
Newbie friendliness
25/100

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