OpenFreeEnergy / OpenFreeEnergy/feflow

Add `num_cycle_laps` setting to `NonEquilibriumCyclingProtocol`, allowing for additional NEQ iterations within each `CycleUnit`

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#102 9 comments 0 reactions 1 assignee View on GitHub

@ijpulidos is already working on this.

Since Dec 16, 2024.

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Python
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Description

In some contexts, such as Folding@Home use, it may make sense to perform additional nonequilibrium cycling sampling within each CycleUnit beyond just a single equil A -> A->B -> equil B -> B->A iteration. This would enable more nonequilibrium work values to be sampled from a single CycleUnit without merely extending the number of steps of each segment within the iteration.

To achieve this, could we add a num_cycle_laps settings parameter to NonEquilibriumCyclingSettings, and have this make the PeriodicNonequilibriumIntegrator produce multiple laps of its periodic iteration?

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