Merck / Merck/mRNAid

Feature Request: Custom Codon Tables

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Dominant language
Jupyter Notebook
Stars
17
Forks
15
PR merge metrics
No merged PRs in 30d

Description

Great work folks!
I was using dnachisel for non-model organisms, and wondered if it would be reasonable to allow the substitution of a custom codon frequency table from an uploaded JSON or CSV.

I think I can volunteer a snippet to convert a pandas df to the nested dictionary format that dnachisel wants.

potential impact: this might cause interface logic problems with your new codon-pair additions.

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First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start by tracing how the project currently supplies codon frequency tables and how uploaded data is handled. Review the potential interface impact of the codon-pair additions mentioned in the issue. Done means custom tables can be supplied from JSON or CSV without breaking those additions, with the expected nested dictionary format defined.

Written by the indexing model from the issue text.

Assessment

Tech stack
jupyter-notebook, pandas
Domain
bioinformatics
Issue type
Feature
Difficulty
5/5
Estimated time
Over a week
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
25/100

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