Merck / Merck/BioPhi

Allowing humanization to make multiple outputs

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Dominant language
Python
Stars
265
Forks
65
PR merge metrics
No merged PRs in 30d

Description

Currently, the output of the humanization step returns a single fasta file. I would be interested in having the output have multiple sequences that are based on sampling from the output from the model.
I have a POC to do this in the cli, we could discuss what this would look like in the web client if needed.

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First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

Start by reviewing the existing humanization step and the proof of concept in the CLI, then compare how the web client currently handles its single FASTA output. Define how sampling should produce multiple sequences and how both clients should expose them; the work is done when the agreed behavior is implemented and verified for both output paths.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
cli, machine-learning, web-dev
Issue type
Feature
Difficulty
5/5
Estimated time
Over a week
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
25/100

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