Error with running IronPython 3.4.1 on existing Windows .NET4.7.2 project

Prerequisites

I'm working to add the latest stable version of IronPython to a large existing project. This project runs .NET 4.7.2, built for Windows x64 and built on Windows 10 with Visual Studio 2022. IronPython was added via NuGet.

I've had this issue for quite a while and have done a significant amount of research, but there is not much information on this topic.

Description

When running IronPython the initialization of an engine with Python.CreateEngine(); functions properly, but when I attempt to execute engine.Execute(code, scope); with the correct relevant code string and scope object I get a PlatformNotSupportedException. I have had a great deal of trouble trying to find the cause of this issue. This is the specific error:

PlatformNotSupportedException: Operation is not supported on this platform.
  at Microsoft.Scripting.Interpreter.LightLambda.MakeRunDelegateCtor (System.Type delegateType) [0x001f4] in <9784853821ea47dbb6bb1f3e03091049>:0 
  at Microsoft.Scripting.Interpreter.LightLambda.GetRunDelegateCtor (System.Type delegateType) [0x00023] in <9784853821ea47dbb6bb1f3e03091049>:0 
  at Microsoft.Scripting.Interpreter.LightLambda.MakeDelegate (System.Type delegateType) [0x00000] in <9784853821ea47dbb6bb1f3e03091049>:0 
  at Microsoft.Scripting.Interpreter.LightDelegateCreator.CreateDelegate (System.Runtime.CompilerServices.StrongBox`1[System.Object][] closure) [0x00047] in <9784853821ea47dbb6bb1f3e03091049>:0 
  at Microsoft.Scripting.Interpreter.LightDelegateCreator.CreateDelegate () [0x00000] in <9784853821ea47dbb6bb1f3e03091049>:0 
  at Microsoft.Scripting.Ast.LightExpression`1[T].Compile (System.Int32 compilationThreshold) [0x0000c] in <9784853821ea47dbb6bb1f3e03091049>:0 
  at IronPython.Compiler.PythonScriptCode.CompileBody (Microsoft.Scripting.Ast.LightExpression`1[T] lambda) [0x00057] in <57a5bd653356491bba8a61ecf9211193>:0 
  at IronPython.Compiler.PythonScriptCode.EnsureTarget (System.Boolean register) [0x00015] in <57a5bd653356491bba8a61ecf9211193>:0 
  at IronPython.Compiler.PythonScriptCode.GetTarget (System.Boolean register) [0x00021] in <57a5bd653356491bba8a61ecf9211193>:0 
  at IronPython.Compiler.PythonScriptCode.RunWorker (IronPython.Runtime.CodeContext ctx) [0x00000] in <57a5bd653356491bba8a61ecf9211193>:0 
  at IronPython.Compiler.PythonScriptCode.Run (Microsoft.Scripting.Runtime.Scope scope) [0x00023] in <57a5bd653356491bba8a61ecf9211193>:0 
  at IronPython.Compiler.RuntimeScriptCode.InvokeTarget (Microsoft.Scripting.Runtime.Scope scope) [0x000c6] in <57a5bd653356491bba8a61ecf9211193>:0 
  at IronPython.Compiler.RuntimeScriptCode.Run (Microsoft.Scripting.Runtime.Scope scope) [0x00000] in <57a5bd653356491bba8a61ecf9211193>:0 
  at Microsoft.Scripting.SourceUnit.Execute (Microsoft.Scripting.Runtime.Scope scope, Microsoft.Scripting.ErrorSink errorSink) [0x0001e] in <0d164baeace648b2930cfd25249cf9f3>:0 
  at Microsoft.Scripting.SourceUnit.Execute (Microsoft.Scripting.Runtime.Scope scope) [0x00000] in <0d164baeace648b2930cfd25249cf9f3>:0 
  at Microsoft.Scripting.Hosting.ScriptSource.Execute (Microsoft.Scripting.Hosting.ScriptScope scope) [0x00017] in <0d164baeace648b2930cfd25249cf9f3>:0 
  at (wrapper remoting-invoke-with-check) Microsoft.Scripting.Hosting.ScriptSource.Execute(Microsoft.Scripting.Hosting.ScriptScope)
  at **[CALLING OBJECT]**..ctor () [0x00020] in . . .

Any help or recommendations on project details I need to verify would be greatly appreciated. Thanks!

Start by reproducing the reported call sequence, Python.CreateEngine() followed by engine.Execute(code, scope), in a Windows x64 .NET 4.7.2 project using the IronPython NuGet package. Review the Microsoft.Scripting and IronPython stack trace and verify the project and runtime details; done means identifying the cause of the PlatformNotSupportedException and documenting a confirmed resolution.