SPEC application doesn't execute after launching from DynamoRIO

I'm trying to run SPEC CPU2017 on Skylake (Intel Xeon) system. It is a fairly large application and we are seeing that application won't even start when launched by Dynamo RIO. I'm using knobs to control the start point of trace collection and collection size (instruction count).

/root/DynamoRIO-x86_64-Linux-7.90.18019-0/bin64/drrun -t drcachesim -trace_after_instrs 90000000 -exit_after_tracing 80000000 -- /bin/sh /root/specpu2017/bin/runcpu --config=dummy-try2.cfg SPECspeed2017_int_base
Hit delay threshold: enabling tracing.

(15 minutes). I'm considering breaking through gdb. Do you have any suggestions on how to trouble-shoot this issue. Does it happen to all large applications.