Benjamin-Lee / Benjamin-Lee/deep-rules

New paper on DA for scRNA-seq

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Description

[Single-cell RNA-seq denoising using a deep count autoencoder](https://www.nature.com/articles/s41467-018-07931-2#ref-CR33)

> **Denoising enables discovery of subtle cellular phenotypes**

> After having evaluated DCA against competing methods, we tested if DCA denoising could enhance biological discovery which is impossible or more challenging to obtain without denoising. Stoeckius et al. highlight the potential for integrated and multimodal analyses to enhance the discovery of cellular phenotypes, particularly when differentiating between cell populations with subtle transcriptomic differences. (...) After denoising, the two sub-populations of NK cells become visually more clearly evident based on DCA denoised NCAM1 and FCGR3A RNA expression levels .

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Assessment

Tech stack
machine-learning
Domain
bioinformatics, content, documentation
Issue type
Documentation
Difficulty
2/5
Estimated time
1-3 hours
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
35/100

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