Unresponsive Central Buttons

I noticed that I can't click on UI buttons near the center of the screen. The button will appear highlighted, but clicking it doesn't do anything. The pause menu and main menu work fine though. It's only in game. Usually, the problem only starts midway through the ancient era.
UD: Uninstalling CQUI and reinstalling individual components (production queue, better trade screen, etc) recreates the problem.
OS: Windows 10
Vanilla

Start by reproducing the unresponsive central buttons in Civilization VI on Windows 10, using the vanilla game and the listed CQUI components, and note whether the issue begins in the ancient era. Compare input behavior for in-game central buttons with the working pause and main menus; done means those buttons respond reliably with the affected components installed.

Written by the indexing model from the issue text.