Files Randomly Truncated

I have been seeing a difficult-to-track-down problem where files seemingly randomly get truncated. I have a strong belief this happens during horizontal scaling. I most-recently saw this with the file /home/site/wwwroot/wp-content/advanced-cache.php, which is used by WP Super Cache, where the file was truncated. This took down our site until I removed the file so the plugin could recreate it.

Is there a quirk with NFS that we should be careful-of? Do plugins need to explicitly handle shared file systems?