Caching works for some hours, then starts complaining about directories not existing - stops caching

Has happened several times for the same site in about one week.
I then have to disable/activate, delete wp-cache-config, delete the plugin folder etc, and it suddenly works again.
Seems random what makes it work again, and then after a day or two it stops with the same error, from the log file:
```

wpcache_do_rebuild: doing rebuild for wwwroot\wp-content/cache/supercache/etc/etc/
/etc/etc/ wpcache_do_rebuild: exiting as directory is not a directory: D:\home\site\wwwroot\wp-content/cache/supercache/etc/etc

wpsc_get_realpath: directory does not exist - D:\home\site\wwwroot\wp-content/cache/supercache/etc/
33332 / wp_cache_get_ob: not caching as directory does not exist.
```

Any ideas?