AllenInstitute / AllenInstitute/cell_type_mapper

How to apply cell_type_mapper on Spinal cord

Open
#41 3 comments 0 reactions 0 assignees View on GitHub

Nobody has claimed this yet.

Dominant language
Python
Stars
55
Forks
9
PR merge metrics
No merged PRs in 30d

Description

Hi,

I understand that the Cell Type Mapper was originally designed for brain cell type mapping. I'm interested in applying it to mouse spinal cord data and would appreciate your guidance on a few points:

Since cell type markers in the spinal cord may differ from those in the brain, would it be advisable to incorporate a spinal cord snRNA-seq or scRNA-seq reference dataset into the model?

If so, what would be the recommended approach for integrating a spinal cord reference study into the existing framework?

Any suggestions or guidance would be greatly appreciated. Thank you very much!

Best,
Jingyao

Contributor guide

Open the contributing guide

First steps

  1. Read the whole issue, then the project's contributing guide.
  2. Comment on the issue to say you are picking it up — it saves two people doing the same work.
  3. Fork the repository and make your change on a branch.
  4. Open a pull request that references the issue number.

Research direction

No files, tests, or entry points are named. Start by reviewing the existing Cell Type Mapper reference-data workflow and documentation, then determine whether a spinal cord reference can be integrated and what configuration or preprocessing it requires. Done means providing clear, project-specific guidance for applying the mapper to mouse spinal cord data.

Written by the indexing model from the issue text.

Assessment

Tech stack
python
Domain
bioinformatics
Issue type
Documentation
Difficulty
5/5
Estimated time
Over a week
Activity status
Quiet
Clarity
Needs clarification
Newbie friendliness
25/100

Get new issues in your inbox

A short digest of beginner-friendly GitHub issues.