AllenInstitute / AllenInstitute/MIES
Ignore symmetric deconvolution timeseries
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Description
Analysis of current clamp data with PSX results in deconvolution traces that surpass reasonable detection thresholds but are not associated with actual synaptic events. A feature of these false positives is that the deconvolved traces are symmetric (see image). Would it be possible to filter out these false positives by looking for symmetry in the deconvolved trace? Perhaps a search for an equal opposite sign threshold within a time window would be sufficient.
Open question: should this be an operation where the user can turn it off and adjust other related parameters?
blue box: false positive with symmetric deconvolved trace
green box: miniature EPSP (excitatory post-synaptic potential)
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Research direction
Start by examining current-clamp analysis with PSX and the deconvolution traces shown in the issue. Investigate whether symmetric traces can be identified using an opposite-sign threshold within a time window; the operation's configurability and final acceptance criteria remain open questions.
Written by the indexing model from the issue text.
Assessment
- Domain
- data
- Issue type
- Feature
- Difficulty
- 5/5
- Estimated time
- Over a week
- Activity status
- Stale
- Clarity
- Needs clarification
- Newbie friendliness
- 25/100