AlexsLemonade / AlexsLemonade/sc-data-integration

Future thought: Explore disagreements between references

Open
#220 0 comments 0 reactions 0 assignees View on GitHub
Dominant language
HTML
Stars
0
Forks
0
PR merge metrics
No merged PRs in 30d

Description

This plot seems to me to be possibly the most useful one here. I am particularly interested by just comparing the blueprint to HPCA data, which seem to actually disagree on the labels "common myeloid progenitor" and "granulocyte monocyte progenitor" for a significant portion of cells. Blueprint "wins" here, but I honestly don't know what to make of that: is it a better reference, or just better matched to this dataset?

I think it might be interesting to plot a matrix of comparison between the the combined data and each reference, ideally some kind of annotation of the relationships among labels: when two references disagree, is there a parent/child relationship between the labels? We'd have to dive further into the ontology to create such a plot, so I think it is out of scope for this notebook. We would want to spend some time sketching out designs before trying to actually generate the plot, so this is a long-term thought.

_Originally posted by @jashapiro in https://github.com/AlexsLemonade/sc-data-integration/pull/219#discussion_r1207092879_

Contributor guide

No contributing guide indexed for this repository

Research direction

Begin by reviewing the existing notebook and the plot comparing Blueprint with HPCA data. The proposed work is to sketch and then generate a matrix comparing combined data with each reference, including ontology relationships such as parent and child labels; done means an agreed design and a useful comparison plot.

Written by the indexing model from the issue text.

Assessment

Domain
data, data-visualization
Issue type
Feature
Difficulty
5/5
Estimated time
Over a week
Activity status
Stale
Clarity
Needs clarification
Newbie friendliness
25/100

Get new issues in your inbox

A short digest of beginner-friendly GitHub issues.